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High Levels of CXCL5 Found in Sun-burnt Skin Samples - - UK Researchers Found Clues to Sunburn Pain

High Levels of CXCL5 Found in Sun-burnt Skin Samples

A chemical in the body that triggers pain from sunburn has been pinpointed by UK experts in a discovery that could lead to new painkillers.

Scientists hope one day to be able to knock out the substance with drugs, helping people who suffer from chronic pain.

Tests on volunteers showed CXCL5, as it is called, is produced when skin is burnt by UV rays from the sun.

The research is published in the journal Science Translational Medicine.



Exposure to ultraviolet light from sunlight causes premature skin aging, cancer and other skin changes.

UVB affects the outer layer of skin, and is the main agent responsible for sunburn.

In the study, scientists at King's College London exposed small patches of the 10 volunteers' skin to UVB.

Areas of sunburn were produced which became increasingly tender over a few days.

The scientists took small samples of sun-burnt skin and screened them for hundreds of known pain molecules. They discovered unusually high levels of CXCL5.

Study leader Professor Steve McMahon from the Wolfson Centre for Age-Related Diseases at King's College said: "These findings have shown for the first time the important role of this particular molecule in controlling pain from exposure to UVB irradiation.

"But this study isn't just about sunburn - we hope that we have identified a potential target which can be utilised to understand more about pain in other inflammatory conditions like arthritis and cystitis.

"I'm excited about where these findings could take us in terms of eventually developing a new type of analgesic for people who suffer from chronic pain."

Dr David Bennett, a neurologist at King's College Hospital, added: "We intend to extend this approach to other types of pain and in particular to study patients suffering from chronic pain with the hope that this will speed up the process of turning science into effective treatments for patients."


Source: BBC

33 Deaths Reported Across Europe Due to E.coli Outbreak -- More Deaths Warned by Germnay's Health Minister

33 Deaths Reported Across Europe Due to E.coli Outbreak

BERLIN, Germany – Authorities in Germany have identified the source of the E.coli outbreak as being vegetable sprouts from an organic farm in Lower Saxony, northern Germany.

E. coli outbreak has killed 32 people already in Germany, While Mr Daniel Bahr, Health Minister of Germany, warned of more possible deaths even the source of infection has been identified. 

Daniel Bahr, talking to Bild am Sonntag newspaper, said, “'More fatalities cannot be ruled out, painful though it is to say so.”

The decreasing number of people being infected was a healthy sign; but it couldn’t rule out more cases of E.coli infection; he further added.

Reportedly, more than 3,000 got infected with E.coli in 14 European countries while the death of a Swedish woman is reported, who recently travelled to Germany, other than 32 deaths confirmed in Germany.

Roller-Shaper: Get Trimmed Without Heavy Workout in the Gyms (Must See Video)

A lot of people are continuously looking for a way to lose weight without having to really exercise or workout, and the Roll-Shaper may be another option that gets the plump to the gym more effectively than a treadmill does.

Roller-Shaper: Get Trimmed Without Heavy Workout in the Gyms

Roller-Shaper, the rotating body massager is large enough to press your back, thighs, butt and belly and it comes with instructions for several “workouts” that involve holding different positions against the mechanical roller. 

Although the weight loss claim may be a little contentious, the manufacturers emphasize that the Roll-Shaper has great results for lymphatic drainage and ultimately for overall health. The image of a room full of Roll-Shapers rather than cross-trainers may remain surprising for some, but so long as users see some physiological result, this may be worth a try. 

Just watch out the Roller-Shaper machine in action here in the video clip.

Timothy Ray Brown: The Berlin Patient - First Man in History Cured of HIV/AIDS - - Watch the Video

Timothy Ray Brown: The Berlin Patient - First Man in History Cured of HIV/AIDS

SAN FRANCISCO — It has been now three decades since the world came to know about HIV, the virus that causes AIDS. About 30 million people have fallen prey to this killer disease and 7,000 people a day are infected with HIV around the world.

But now a ray of hope has emerged from almost nowhere for the infected patients of HIV.

Timothy Ray Brown, also known as ‘Berlin Patient’, resident of the Bay Area may be the first person ever cured of the deadly disease AIDS, the result of the discovery of an apparent HIV immunity gene.

The 45-year-old Brown tested positive for HIV back in 1995, but has now entered scientific journals as the first man in world history to have that HIV virus completely eliminated from his body in what doctors call a "functional cure."

Brown talked to CBS Channels. Just watch the video for more information.

HIV/AIds on the Rise in UK - Infected Patients will Cross 100,000 by the Year 2012: HPA Study

HIV/AIDS to rise in UK: HPA

LONDON (June 07) – It has been three decades since the first HIV/AIDS case came into light in June 1981 in Los Angeles.

To mark the 30^th anniversary of first HIV/AID; UK-based Health Protection Agency (HPA) presented a new report that suggests that number of HIV/AIDS patients in UK could rise to 100,000 by the end of next year.

The latest available figure of HIV patients is 86,500 (according to 2009) in UK which could rise to 100,000, according to HPA. The Health Protection Agency (HPA) has predicted the rise assuming different factors unchanged like encouraging behaviour change, more prevention, routine testing as part of expanded HIV testing policies, and earlier diagnosis.

The data collected by HPA for the latest study shows that since the first diagnosis of HIV was made in 1981, there have been 115,000 infections diagnosed in the UK alone. Of these people diagnosed with this once deadly infection 27,000 have developed full blown AIDS and 20,000 have died.

E. coli/HUS outbreak: source still mystery - - 365 news cases reported today (Wednesday/June 1)

BERLIN, Germany (June 1) — The German government is still unable to find the real source of E. coli outbreak while 365 news cases of E. coli have been registered on Wednesday (June 1).

365 E. coli/HUS case reported today (Wednesday/June1)

According to Robert Koch Institute of Germany; almost 1/4th of the new cases involved the hemolytic-uremic syndrome (HUS), a dangerous complication resulting from E. coli infection that affects the blood and kidneys.

As per latest reports, total 16 deaths have been reported in north Europe and an unfortunate common factor among all is that all of them have traveled northern Germany in the last days of their lives.

As one of the biggest outbreak of its type; HUS/E. coli has already effected more than 1,500 in Germany only while the authorities have been unable to identify the source of the virulent strain of E. coli.

In early days of E. coli outbreak; German authorities have blamed the Spanish produce as the source of the outbreak after some cucumbers tested positive for the bacteria; but on Tuesday authorities in Hamburg established that the E. coli found on Spanish cucumbers is not the one that is killing people in Europe.

Spain’s per week loss of sales is almost US$287.5-million due to the false blame from German authorities which is a really big one for Spain, which already has the highest unemployment rate in the European Union. Therefore, Spain considering to take legal action against authorities in Hamburg for blaming its produce for the E. coli outbreak.